Emergence and rapid dissemination of highly resistant NDM-14-producing Klebsiella pneumoniae ST147, France, 2022

Carbapenems remain one of the last-line options to treat infections caused by highly resistant Enterobacterales, but production of carbapenemase enzymes is one of the main resistance mechanisms to carbapenems in these bacteria. Accordingly, the increasing dissemination of carbapenemase-producing Enterobacterales (CPEs) poses a global threat to public health. 

The recent and rapid emergence of NDM-14-producing K. pneumoniae ST147 isolated from patients in France directly repatriated from Morocco suggests a spread of this clone particularly in the Casablanca region. This clone likely emerged recently from an endemic NDM-1-producing K. pneumoniae ST147.